| När? | Lag (Borta vs. Hemma) | Resultat | Målskyttar |
| 10/10 | Panthers - Oilers | 2-3 | Reasoner(2) |
| 11/10 | Panthers - Canucks | 1-2 | Olesz |
| 14/10 | Panthers - Flames | 3-0 | Dvorak(2), Matthias |
| 16/10 | Lightning - Panthers | 0-6 | Stillman, Booth(2), Reinprecht, Wideman, Olesz |
| 21/10 | Stars - Panthers | 4-1 | Weiss |
| 23/10 | Islanders - Panthers | 3-4 | Weaver, Bernier, Booth, Dvorak |
| 26/10 | Panthers - MapleLeafs | 1-3 | Wideman |
| 28/10 | Panthers - Senators | 3-5 | McCabe, Higgins, Santorelli |
| 30/10 | Panthers - Canadiens | 3-1 | Frolik, Booth, Matthias |
| 3/11 | Thrashers - Panthers | 4-3 | Garrison, Reinprecht, Allen |
| 5/11 | Hurricanes - Panthers | 4-7 | Booth, Weiss(2), Santorelli, Higgins, Reasoner, Frolik |
| 6/11 | Panthers - Hurricanes | 2-3 | Hordichuk, Frolik |
| 10/11 | MapleLeafs - Panthers | 1-4 | Allen, Reinprecht, Matthias, Frolik |
| 12/11 | Wild - Panthers | 1-2 | Higgins, Santorelli |
| 13/11 | Panthers - Flyers | 2-5 | Stillman, Santorelli |
| 17/11 | Panthers - Thrashers | 2-1 | Weiss, Dvorak |
| 18/11 | Panthers - Bruins | 0-4 | |
| 20/11 | Panthers - Islanders | 4-1 | Santorelli 2, Reasoner, Weiss |
| 22/11 | Penguins - Panthers | 3-2 | Stillman, McCabe |
| 24/11 | Bruins - Panthers | 3-1 | Reinprecht |
| 26/11 | Rangers - Panthers | 3-0 | |
| 27/11 | Panthers - Lightning | 4-3(SO) | Dvorak, Kulikov, Matthias, Weiss(SO) |
| 1/12 | Panthers - Ducks | 3-5 | Santorelli, Bernier 2 |
| 2/12 | Panthers - Kings | 2-3 | Repik, Booth |
| 4/12 | Panthers - Coyotes | 2-1(SO) | Frolik, Frolik(SO) |
| 7/12 | Avalanche - Panthers | 3-4(OT) | Thomas, Weiss 2, Booth |
| 9/12 | Panthers - Capitals | 3-0 | Frolik, Bernier, Santorelli |
| 11/12 | Panthers - Predators | 0-3 | |
| 15/12 | Hurricanes - Panthers | 4-3 | Dadonov, Frolik, McCabe |
| 17/12 | Sabres - Panthers | 2-6 | McCabe, Reasoner 2, Booth, Frolik, Weiss |
| 20/12 | Panthers - Flyers | 5-0 | Thomas, Dadonov, Mathias, Santorelli, Kulikov |
| 22/12 | Panthers - Penguins | 2-5 | Weiss, McCabe |
| 23/12 | Panthers - Sabres | 4-3 | Higgins 2, Weiss, Garrison |
| 27/12 | Bruins - Panthers | 3-2(SO) | Booth, Santorelli |
| 31/12 | Canadiens - Panthers | 3-2(OT) | Weiss, Kulikov |
| 2/1 | Rangers - Panthers | 0-3 | Booth, Higgins, Weiss |
| 3/1 | Panthers - Hurricanes | 4-3(OT) | Wideman, Higgins, Stillman, Allen |
| 5/1 | Thrashers - Panthers | 3-2 | Weiss, Higgins |
| 7/1 | Hurricanes - Panthers | 5-3 | Booth, Reasoner(2) |
| 8/1 | Panthers - Capitals | 2-3 | Santorelli, Dadonov |
| 11/1 | Capitals - Panthers | 3-4(OT) | Santorelli, Reasoner, Booth, Wideman |
| 13/1 | Predators - Panthes | 2-3 | Dvorak, Olesz, Booth |
| 15/1 | Devils - Panthers | 2-3(OT) | Dadonov, Wideman, Kulikov |
| 17/1 | Thrashers - Panthers | 3-2(SO) | Wideman, Kulikov |
| 19/1 | Blue Jackets - Panthers | 3-2(OT) | Booth, Stillman |
| 21/1 | Lightning - Panthers | 2-1(SO) | Stillman |
| 23/1 | Panthers - Devils | 2-5 | Matthias, Reasoner |
| 25/1 | Panthers - Rangers | 4-3 | Olesz, Santorelli, Ellerby, Weaver |
| 26/1 | Panthers - Bruins | 1-2 | Allen |
| 1/2 | Panthers - Maple Leafs | 3-4(SO) | Weiss, Booth, Stillman |
| 2/2 | Panthers - Canadiens | 2-3 | TImmins, Weiss |
| 4/2 | Panthers - Devils | 4-3(OT) | Higgins, Wideman, Santorelli, Olesz |
| 8/2 | Blues - Panthers | 2-1 | Wideman |
| 10/2 | Sabres - Panthers | 3-2(OT) | Bernier, Reasoner |
| 13/2 | Sharks - Panthers | 2-3 | Santorelli, Higgins, Garrison |
| 16/2 | Flyers - Panthers | 4-2 | Olesz, Booth |
| 18/2 | Red Wings - Panthers | 4-3 | Dvorak, Wideman, Weiss |
| 19/2 | Panthers - Lightning | 3-2(SO) | Booth, Santorelli |
| 21/2 | Panthers - Islandes | 1-5 | Santorelli |
| 23/2 | Panthers - Senators | 1-5 | Higgins |
| 25/2 | Panthers - Thrashers | 2-1(SO) | Reasoner |
| 27/2 | Devils - Panthers | 2-1 | Reasoner |
| 1/3 | Panthers - Hurricanes | 1-2 | Weiss |
| 3/3 | Canadiens - Panthers | 4-0 | |
| 5/3 | Panthers - Thrashers | 3-4(OT) | Samsonov, Weiss, Booth |
| 6/3 | Capitals - Panthers | 3-2(OT) | Thomas, Booth |
| 8/3 | Blackhawks - Panthers | 2-3 | Booth, Wilson, Reasoner |
| 10/3 | Senators - Panthers | 2-1 | Wilson |
| 12/3 | Lightning - Panthers | 3-4(OT) | Booth, Carter, Bergfors, Garrison |
| 15/3 | Flyers - Panthers | 3-2 | Weiss, Kulikov |
| 17/3 | Maple Leafs - Panthers | 0-4 | Samsonov, Weiss, Santorelli, Ellerby |
| 19/3 | Islanders - Panthers | 4-3(SO) | Dadonov(2), Weiss |
| 22/3 | Panthers - Rangers | 0-1 | |
| 23/3 | Panthers - Blackhawks | 0-4 | |
| 25/3 | Panthers - Sabres | 2-4 | Samsonov, Dadonov |
| 27/3 | Panthers - Penguins | 1-2(SO) | Carter |
| 29/3 | Panthers - Blue Jackets | 2-3(SO) | Booth, Dadonov |
| 31/3 | Senators - Panthers | 4-1 | Repik |
| 2/4 | Penguins - Panthers | 4-2 | Skille, Wilson |
| 6/4 | Panthers - Capitals | 2-5 | Booth, Santorelli |
| 8/4 | Panthers - Lightning | 2-4 | Garrison, Santorelli |
| 9/4 | Capitals - Panthers | 0-1 | Thomas |
Matcher 2009-10
